Specificity of antinuclear antibodies in primary biliary cirrhosis.
نویسندگان
چکیده
منابع مشابه
Prevalence and clinical significance of isotype specific antinuclear antibodies in primary biliary cirrhosis.
BACKGROUND Antinuclear antibodies (ANA) giving a rim-like/membranous (RL/M) or a multiple nuclear dot (MND) pattern are highly specific for primary biliary cirrhosis (PBC). Aim and SUBJECTS To assess the prevalence of PBC specific ANAs, their Ig isotype, and their clinical significance in 90 PBC patients from Greece and Spain. Twenty eight patients with chronic hepatitis C, 23 patients with s...
متن کاملMitochondrial Antibodies in Primary Biliary Cirrhosis
The antigen reacting with complement-fixing antibodies in the sera of patients with primary biliary cirrhosis was localized predominantly in the mitochondrial fraction of tissue homogenates obtained by differential centrifugation. Purified mitochondrial preparations had a high content of the antigen whereas purified lysosomes failed to fix complement with PBC sera. Analysis of a number of fract...
متن کاملApotopes and the biliary specificity of primary biliary cirrhosis.
UNLABELLED Primary biliary cirrhosis (PBC) is characterized by antimitochondrial antibodies (AMAs), directed to the E2 component of the pyruvate dehydrogenase complex (PDC-E2). Notwithstanding the presence of mitochondria in virtually all nucleated cells, the destruction in PBC is limited to small intrahepatic bile ducts. The reasons for this tissue specificity remain unknown, although biliary ...
متن کاملAntimitochondrial and antinuclear antibodies in primary biliary cirrhosis: an update in relation to their biochemical characterization and clinical significance.
Antimitochondrial antibodies are found in 85 to 95% of patients with primary biliary cirrhosis. Nine different patterns have been identified but only four are associated with primary biliary cirrhosis. Anti-M2 antibodies are specific for the disease. The M2 antigen was found to be composed of five antigen determinants and related to the E2 component of three multienzyme complexes located within...
متن کاملPrimary Biliary Cirrhosis-Specific Antimitochondrial Antibodies in Neonatal Haemochromatosis
BACKGROUND AND AIM Neonatal hemochromatosis (NH) is characterised by severe liver injury and extrahepatic siderosis sparing the reticuloendothelial system. Its aetiology is obscure, although it has been proposed as an alloimmune disease, resulting from immunological reaction to self-antigens (alloantigens) which the body recognizes as foreign. We studied an infant with NH and his mother whose s...
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ژورنال
عنوان ژورنال: Annals of the Rheumatic Diseases
سال: 1995
ISSN: 0003-4967
DOI: 10.1136/ard.54.2.148